4,5-trihydroxy-7-methoxy-9H-fluoren-9-one, a new cytotoxic compound from Dendrobium chrysotoxum

作者：Chen Yegao^*; Li Yupeng; Qing Chen; Zhang Yanli; Wang Liqin; Liu Ying

来源：Food Chemistry, 2008, 108(3): 973-976.

DOI：10.1016/j.foodchem.2007.12.007

• Dendrobium chrysotoxum
• Orchidaceae
• fluorenones
• 1,4,5-Trihydroxy-7-methoxy-9H-fluoren-9-one
• cytotoxicity

A new compound, 1,4,5-trihydroxy-7-methoxy-9H-fluoren-9-one, has been isolated together with two known fluorenones, dendroflorin and denchrysan A, from the whole plant of Dendrobium chrysotoxian, a plant of Dendrobium genus, used as a health-food. The structure of the fluorenones has been determined on the basis of spectroscopic studies. The isolated compounds were evaluated in vitro for their inhibitory ability against the growth of human leukaemia cell lines K562 and HL-60, human lung adenocarcinoma A549, human hepatoma BEL-7402 and human stomach cancer SGC-7901. All three fluorenones displayed selective cytotoxicity against BEL-7402 with IC50 values of 1.49, 0.97 and 1.38 mu g/ml, respectively.

• 出版日期2008-6-1
• 单位云南师范大学; 昆明医科大学