A New Coumarin and Cytotoxic Activities of Constituents from Cinnamomum cassia

作者：Tran Minh Ngoc; Nguyen Xuan Nhiem; Nguyen Minh Khoi; Doan Cao Son; Tran Viet Hung; Phan Van Kiem^*

来源：Natural Product Communications, 2014, 9(4): 487-488.

DOI：10.1177/1934578x1400900414

• Cinnamomum cassia
• Ramulus cinnamomi
• Coumacasia
• Cytotoxic activity

A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and cinnamic alcohol (9), were isolated from the methanol extract of Cinnamomum cassia. Their structures were elucidated by spectral data and by comparison with the reported literature. The cytotoxic activities of compounds 1-9 were evaluated with two human cancer cell lines, HL-60 and A-549. Compound 1 showed growth inhibitory effects in the HL-60 and A-549 cell lines with IC50 values of 8.2 +/- 0.5 and 11.3 +/- 1.1 mu M, respectively. Compounds 3-6, and 8 exhibited moderate cytotoxicity with IC50 values ranging from 20.5 to 65.6 mu M.

• 出版日期2014-4
• 单位河北医科大学