A dosimetric comparison of double-arc volumetric arc therapy, step-shoot intensity modulated radiotherapy and 3D-CRT for left-sided breast cancer radiotherapy after breast-conserving surgery

作者：Mo, Jun-Cong; Huang, Jin; Gu, Wen-Dong; Gao, Min; Ning, Zhong-Hua; Mu, Jin-Ming; Li, Qi-Lin; Pei, Hong-Lei^*

来源：Technology and Health Care, 2017, 25(5): 851-858.

DOI：10.3233/THC-160746

• Left-sided breast-conserving surgery
• double-arc volumetric arc therapy
• step-shoot intensity modulated radiotherapy
• 3D-CRT
• dosimetry

OBJECTIVE: To compare the dosimetric and efficiency differences for left-sided breast cancer radiotherapy after breast-conservingsurgery among three different planning techniques: double-arc volumetric-modulate arc therapy (VMAT), step-shoot intensity-modulated radiotherapy (sIMRT) and three-dimensional conformal radiation therapy (3D-CRT).
MATERIALS AND METHODS: A total of 17 female patients with left-sided breast cancer who underwent breast-conserving surgery were selected; the prescription doses were 50 Gy in 25 fractions. For every patient VMAT, sIMRT and 3D-CRT plans were generated within the Monaco treatment planning system for an Axesse (TM) accelerator equipped with the Agility MLC. The Conformity Index (CI), the Homogeneity Index (HI), the dose volume histogram (DVH) parameters for the organs at risk and the delivery efficiency were evaluated.
RESULTS: The VMAT plans showed on average higher CI of PTV (0.77 +/- 0.03) than both sIMRT (0.68 +/- 0.02) and 3D-CRT (0.55 +/- 0.04) plans (P < 0.05). The HI values in the VMAT, sIMRT and 3D-CRT plans were 0.10 +/- 0.01 0.09 +/- 0.01 and 0.13 +/- 0.01 (P > 0.05), respectively, and the differences among the three techniques were not statistically significant. In the ipsilateral lung, the VMAT plans showed lower D-mean, V-30, V-20, and V-10 than the sIMRT and 3D-CRT (P < 0.05); however, there was no significant difference in V-5. In the heart, the VMAT plans had lower V-30 and V-20 than the sIMRT and 3D-CRT plans (P < 0.05), but there was no significant difference in the Dmean and V-5. In the contralateral lung, the VMAT plans showed higher D-mean and V-5 than sIMRT and 3D-CRT (P < 0.05). In the contralateral breast, the VMAT plans had a higher V-5 than the sIMRT and 3D-CRT plans (P < 0.05). The VMAT plans had higher MU's than sIMRT and 3D-CRT, while the treatment times were lower than that of sIMRT.
CONCLUSION: For left-sided breast cancer radiotherapy after breast-conserving surgery, the VMAT plans had a better CI than the sIMRT and 3D-CRT plans. The VMAT and the sIMRT plans had better HI than the 3D-CRT plans, but no significant difference was observed between VMAT and sIMRT.

• 出版日期2017
• 单位苏州大学