Development and characterisation of polymeric microparticle of pely(D,L-lactic acid) loaded with holmium acetylacetonate

作者：de Azevedo Mariangela de Burgos M; de Melo Vitor H S; Soares Carlos Roberto J; Miyamoto Douglas M; Katayama Ricardo A; Squair Peterson L; Barros Caio H N; Tasic Ljubica

来源：Journal of Microencapsulation, 2018, 35(3): 281-291.

DOI：10.1080/02652048.2018.1477843

• PDLLA
• holmium acetylcetonate
• brachytherapy
• microspheres

Biodegradable polymers containing radioactive isotopes such as Holmium 166 (Ho-166) have potential applications as beta particle emitters in tumour tissues. It is also a gamma ray emitter, allowing nuclear imaging of any tissue to be acquired. It is frequently used in the form of complexes such as holmium acetylacetonate (HoAcAc), which may cause damages in tissues next to the targets cancer cells, as it is difficult to control its linkage or healthy tissues radiotherapy effects. Poly(D,L-lactic add), PDLLA, was used to encapsulate holmium acetylacetonate (HoAcAc) using an emulsion solvent extraction/evaporation technique. Microspheres with sizes between 20-53 mu m were extensively characterised. HoAcAc release from the microspheres was assessed through studies using Inductively Coupled Plasma - Optical Emission Spectroscopy, and the microspheres showed no holmium leakage after a period of 10 half-lives and following gamma irradiation. Thus, HoAcAc loaded microspheres are here presented as a potential system for brachytherapy and imaging purposes.

• 出版日期2018