A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility

作者：Nakayama Akiyoshi; Matsuo Hirotaka^*; Shimizu Takuya; Ogata Hiraku; Takada Yuzo; Nakashima Hiroshi; Nakamura Takahiro; Shimizu Seiko; Chiba Toshinori; Sakiyama Masayuki; Ushiyama Chisaki; Takada Tappei; Inoue Katsuhisa; Kawai Sayo; Hishida Asahi; Wakai Kenji; Hamajima Nobuyuki; Ichida Kimiyoshi; Sakurai Yutaka; Kato Yukio; Shimizu Toru; Shinomiya Nariyoshi

来源：Human Cell, 2013, 26(4): 133-136.

DOI：10.1007/s13577-013-0073-8

• Gouty arthritis
• Single nucleotide polymorphism (SNP)
• Gut urate excretion
• Carnitine
• Solute carrier (SLC) family transporter

Gout is a common disease caused by hyperuricemia, which shows elevated serum uric acid (SUA) levels. From a viewpoint of urate handling in humans, gout patients can be divided into those with renal overload (ROL) gout with intestinal urate underexcretion, and those with renal underexcretion (RUE) gout. Recent genome-wide association studies (GWAS) revealed an association between SUA and a variant in human monocarboxylate transporter 9 (MCT9/SLC16A9) gene. Although the function of MCT9 remains unclear, urate is mostly excreted via intestine and kidney where MCT9 expression is observed. In this study, we investigated the relationship between a variant of MCT9 and gout in 545 patients and 1,115 healthy volunteers. A missense variant of MCT9 (K258T), rs2242206, significantly increased the risk of ROL gout (p = 0.012), with odds ratio (OR) of 1.28, although it revealed no significant association with all gout cases (p = 0.10), non-ROL gout cases (p = 0.83), and RUE gout cases (p = 0.34). In any case groups and the control group, minor allele frequencies of rs2242206 were %26gt;0.40. Therefore, rs2242206 is a common missense variant and is revealed to have an association with ROL gout, indicating that rs2242206 relates to decreased intestinal urate excretion rather than decreased renal urate excretion. Our study provides clues to better understand the pathophysiology of gout as well as the physiological roles of MCT9.

• 出版日期2013-12
• 单位河北医科大学