A Convenient Synthesis of (S)-H-4-BINOL and Its Derivatives via Hydrogenation of Monoesters of BINOL

作者：Li Xinsheng^*; Ding Qianchang; Ge Jianfeng; Xie Jianwu; Xu Dongcheng

来源：Journal of Organic Chemistry, 2009, 74(4): 1785-1787.

DOI：10.1021/jo802542m

A new multigram synthesis of chiral (S)-H-4-BINOL and its derivatives in moderate to high yield (up to 83% total yield) via monoesterification of (S)-BINOL, hydrogenation, and saponification reaction was described. The two new monomethylated (S)-H-4-BINOL obtained may be useful materials in asymmetric catalysis.

• 出版日期2009-2-20
• 单位宿州学院; 苏州大学; 浙江师范大学