Design and synthesis of biologically active analogues of vitamin K-2: Evaluation of their biological activities with cultured human cell lines

作者：Suhara Yoshitomo; Hirota Yoshihisa; Nakagawa Kimie; Kamao Maya; Tsugawa Naoko; Okano Toshio^*

来源：Bioorganic & Medicinal Chemistry, 2008, 16(6): 3108-3117.

DOI：10.1016/j.bmc.2007.12.025

• vitamin K
• metabolite
• menaquinone-4
• omega-oxidation
• K acid

Novel omega-oxygenated vitamin K-2 analogues were efficiently synthesized and their biological activities were evaluated. Some were biologically active and the side-chain played an important role in gamma-carboxylation and apoptosis-inducing activity. The results provide useful information on the structure-activity relationship of vitamin K-2 analogues for the development of new drugs.

• 出版日期2008-3-15