Mitochondrial DNA-based genetic diversity of Anopheles nivipes in North East India

作者：Sarma N P; Singh S; Sarma D K; Bhattacharyya D R; Kalita M C; Mohapatra P K; Dohutia C; Mahanta J; Prakash A^*

来源：Mitochondrial DNA Part A, 2016, 27(6): 4236-4239.

DOI：10.3109/19401736.2015.1022757

• COII gene
• gene flow
• malaria vector
• ND5 gene
• population structure

Malaria is a major public health problem in north-east India mainly transmitted by Anopheles baimai and An. minimus while Anopheles nivipes plays an important supportive role. The genetic diversity of An. nivipes in north-east India was investigated by employing two mitochondrial DNA markers namely NADH dehydrogenase 5 (ND5) and cytochrome oxidase sub unit II (COII). High genetic diversity in An. nivipes was observed by the detection of 16 haplotypes among 30 sequences of ND5 gene and 29 haplotypes among 29 COII sequences. Anopheles nivipes of north-east India was significantly differentiated genetically with that of neighboring South-east Asian An. nivipes as revealed by pairwise F-ST values of 0.127 (p < 0.01) and 0.044 (p < 0.001) for ND5 and COII genes, respectively, suggesting geographical barriers to gene flow in this species between the two geographical areas resulting in significant population structuring.

• 出版日期2016