Arginine Regulates the Homeostasis of Apoptosis and Proliferation of Enterocyte by Changing Insulin/Akt Signal in Intrauterine Growth Retardation Piglets

作者：Wang Yuanxiao^*; Zhang Lili; Wang Tian; Xu Ruojun

来源：International Conference on Agricultural and Biosystems Engineering, 2011-02-20 to 2011-02-21.

• IUGR
• Arginine
• small intestine
• Akt
• piglets

L-arginine (Arg) plays critical roles in promoting small intestinal development of young pigs. Neonatal pigs suffered by intrauterine growth retardation (IUGR) have lower serum Arg and delayed intestinal development. In this study, normal and IUGR piglets were fed milk-based diets supplemented with 0 and 0.6% Arg respectively from 7(th) to 14(th) d of age. The decreased (P < 0.05) level of insulin, phosphorylated Akt may involve in the mechanisms responsible for increased (P < 0.05) apoptosis, and reduced (P < 0.05) proliferation caused by IUGR. Arg supplementation decreased (P < 0.05) apoptosis, apoptosis index: proliferation index, as well as increased (P < 0.05) the levels of insulin, and phosphorylated Akt in small intestinal mucosa of IUGR piglets. These findings suggest that Arg is beneficial in improving the delayed small intestine development caused by IUGR, The changed insulin level and Akt activity involves in a mechanism that regulates the homeostasis of apoptosis and proliferation in small intestinal mucosa.

• 出版日期2011
• 单位南京农业大学