科研之友
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摘要
A facile synthetic approach was adopted towards the synthesis of benzo-fused macrocyclic lactams 2a-2gvia the base-catalyzed condensation reaction of 2,2-[alkanediylbis(oxy)]bis[benzaldehydes] 3a-3c with N,N-substituted bis[2-cyanoacetamide] derivatives 7a-7c (Scheme2). The latter compounds were obtained by the reaction of the appropriate diamines 6a-6c with ethyl 2-cyanoacetate (4). Attempts to prepare the oxaaza macrocycles 2 by alternative pathways were also investigated. The novel pyrazolo-fused macrocycles 13a and 13b were obtained in 48 and 52% yield, respectively, upon treatment of 2d and 2g with NH2NH2H2O at 100 degrees (Scheme4).
- 出版日期2013-7
