Glassy Dynamics, Cell Mechanics, and Endothelial Permeability

作者：Hardin Corey^*; Rajendran Kavitha; Manomohan Greeshma; Tambe Dhananjay T; Butler James P; Fredberg Jeffrey J; Martinelli Roberta; Carman Christopher V; Krishnan Ramaswamy

来源：Journal of Physical Chemistry B, 2013, 117(42): 12850-12856.

DOI：10.1021/jp4020965

A key feature of all inflammatory processes is disruption of the vascular endothelial barrier. Such disruption is initiated in part through active contraction of the cytoskeleton of the endothelial cell (EC). Because contractile forces are propagated from cell to cell across a great many cell-cell junctions, this contractile process is strongly cooperative and highly nonlocal. We show here that the characteristic length scale of propagation is modulated by agonists and antagonists that impact permeability of the endothelial barrier. In the presence of agonists including thrombin, histamine, and H2O2, force correlation length increases, whereas in the presence of antagonists including sphingosine-l-phosphate, hepatocyte growth factor, and the rho kinase inhibitor, Y27632, force correlation length decreases. Intercellular force chains and force clusters are also evident, both of which are reminiscent of soft glassy materials approaching a glass transition.

• 出版日期2013-10-24