科研之友
微信
新浪微博
Facebook
分享链接
摘要
A new class of AuxAg1-x nanostructures with dendrite morphology and a hollow interior were synthesized by using a replacement reaction between Ag dendrites and an aqueous solution of HAuCl4. The Ag nanostructured dendrites were generated by the reaction of AgNO3 with ascorbic acid in a methanol/water system. The dendrites resemble a coral shape and are built up of many stems with an asymmetric arrangement. Each stem is approximately 400 nm in length and 65 nm in diameter. The bimetallic composition of AuxAg1-x can be tuned by the addition of different amounts of HAuCl4 to the Ag dendritic solution. The hollowing process resulted in tubular structures with a wall thickness of 10.5 nm in Au0.3Ag0.7 dendrites. The UV/Vis spectra indicate that the strongest NIR absorption among the resulting hollow AuxAg1-x dendrites was in Au0.3Ag0.7. The MTT assay was conducted to evaluate the cytotoxicity of Ag dendrites, hollow Au0.06Ag0.94 and Au0.3Ag0.7 dendrites, and Au nanorods. It was found that hollow Au0.06Ag0.94 and Au0.3Ag0.7 dendrites exhibited good biocompatibility, while both Ag dendrites and An nanorods showed dose-dependent toxicity. Because of absorption in the NIR region, hollow Au0.3Ag0.7 dendrites were used as photothermal absorbers for destroying A549 lung cancer cells. Their photothermal performance was compared to that of An nanorod photothermal therapeutic agents. As a result, the particle concentration and laser power required for efficient cancer cell damage were significantly reduced for hollow Au0.3Ag0.7 dendrites relative to those used for Au nanorods. The hollow Au0.3Ag0.7 nanostructured dendrites show potential in photothermolysis for killing cancer cells.
- 出版日期2008
- 单位清华大学
