A four-year surveillance program for detection of Plasmodium falciparum chloroquine resistance in Honduras

作者:Fontecha Gustavo A*; Sanchez Ana L; Mendoza Meisy; Banegas Engels; Mejia Torres Rosa E
来源:Memorias do Instituto Oswaldo Cruz, 2014, 109(4): 492-493.
DOI:10.1590/0074-0276140067

摘要

Countries could use the monitoring of drug resistance in malaria parasites as an effective early warning system to develop the timely response mechanisms that are required to avert the further spread of malaria. Drug resistance surveillance is essential in areas where no drug resistance has been reported, especially if neighbouring countries have previously reported resistance. Here, we present the results of a four-year surveillance program based on the sequencing of the pfcrt gene of Plasmodium falciparum populations from endemic areas of Honduras. All isolates were susceptible to chloroquine, as revealed by the pfcrt %26quot;CVMNK%26quot; genotype in codons 72-76.

  • 出版日期2014-6