A convergent synthesis of the [4.4]-spiroacetal-gamma-lactones cephalosporolides E and F

作者：Brimble Margaret A^*; Finch Orla C; Heapy Amanda M; Fraser John D; Furkert Daniel P; O'Connor Patrick D

来源：Tetrahedron, 2011, 67(5): 995-1001.

DOI：10.1016/j.tet.2010.11.107

• Mukaiyama aldol reaction
• Cephalosporolide
• Total synthesis
• Natural products

A short convergent synthesis of the fungal metabolites cephalosporolides E and F is reported. The key step makes use of a chelation-controlled Mukaiyama aldol reaction to access the key acyclic spiroacetal precursor with the required syn stereochemistry.

• 出版日期2011-2-4