Organocatalytic asymmetric ring-opening of aziridines

作者:Paixao Mircio W; Nielsen Martin; Jacobsen Christian Borch; Jorgensen Karl Anker*
来源:Organic and Biomolecular Chemistry, 2008, 6(19): 3467-3470.
DOI:10.1039/b812369a

摘要

The organocatalytic ring-opening of N-tosyl protected aziridines by beta-ketoesters under chiral PTC-conditions, leading to the formation of optically active aminoethyl functionalised compounds with up to 99% ee, has been developed.

  • 出版日期2008-10-7