Associations between hsa-miR-603 polymorphism, lifestyle-related factors and colorectal cancer risk

作者：Wang, Fen-Juan; Ding, Ye; Mao, Ying-Ying; Jing, Fang-Yuan; Zhang, Zhen-Yu; Jiang, Long-Fang; Guo, Jian-Feng; Sun, Xiang-Jue; Jin, Ming-Juan; Chen, Kun^*

来源：Cancer Biomarkers, 2014, 14(4): 225-231.

DOI：10.3233/CBM-140395

• hsa-miR-603
• polymorphism
• colorectal cancer
• susceptibility

BACKGROUND: Accumulated studies have suggested that single nucleotide polymorphisms (SNPs) in microRNAs are associated with risk of colorectal cancer (CRC). @@@ OBJECTIVE: We tested our hypothesis that rs11014002 in hsa-miR-603 may be associated with CRC risk with a crosstalk of life-related factors. @@@ METHODS: We conducted a case-control study which included 102 CRC patients and 204 matched cancer-free controls in Xiaoshan County. @@@ RESULTS: We observed that subjects with rs11014002 CT/TT genotype had an increased susceptibility for CRC (CT vs. CC: odds ratio (OR) = 2.352, 95% confidence interval (CI): 1.142-4.840, P = 0.020; CT+TT vs. CC: OR = 2.031, 95% CI: 1.063-3.883, P = 0.032). After stratification by lifestyle-related factors, similar results were found among nonsmokers (CT vs. CC: OR = 2.753, 95% CI: 1.085-6.983, P = 0.033; CT+TT vs. CC: OR = 2.971, 95% CI: 1.188-7.435, P = 0.020) and non-alcohol drinkers (CT+TT vs. CC: OR = 3.279, 95% CI: 1.071-10.033, P = 0.037). @@@ CONCLUSIONS: Our data suggest that hsa-miR-603 may be involved in colorectal tumorigenesis, and the genetic polymorphism in hsa-miR-603 is associated with CRC susceptibility.

• 出版日期2014
• 单位中国疾病预防控制中心; 浙江大学