Amphidinin G, a putative biosynthetic precursor of amphidinin A from marine dinoflagellate Amphidinium sp.

作者：Kubota Takaaki; Iwai Takahiro; Ishiyama Haruaki; Sakai Kanae; Gonoi Tohru; Kobayashi Jun'ichi^*

来源：Tetrahedron Letters, 2015, 56(8): 990-993.

DOI：10.1016/j.tetlet.2015.01.058

• Dinoflagellate
• Amphidinium sp.
• Linear polyketide
• Biosynthetic precursor
• Antifungal

A new linear polyketide, amphidinin G (1), has been isolated from a symbiotic marine dinoflagellate Amphidinium sp. The planar structure of 1 was established mainly based on the 2D NMR data and the stereochemistry was elucidated by the combination off-value analysis, modified Mosher's method, and NMR chemical shift comparison with synthetic analogues. Amphidinin G (1) was expected to be a biosynthetic precursor of amphidinin A (2), a known linear dinoflagellate polyketide. Amphidinin G (1) showed antifungal activity against Trichophyton mentagrophytes.

• 出版日期2015-2-18