Microwave-assisted synthesis of hydropyridines and study of the DPPH-scavenging activity

作者：Montes Avila Julio^*; Delgado Vargas Francisco; Diaz Camacho Sylvia P; Rivero Ignacio A

来源：RSC Advances, 2012, 2(5): 1827-1834.

DOI：10.1039/c1ra01135a

A series of hydropyridines (HP's) were synthesized using dimedones, ethyl acetoacetate, ammonium acetate and appropriate aldehydes under solvent-free conditions and microwave-irradiation through Hantzsch reaction. All the synthesized HP's were tested in vitro for the 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity and structure-activity relationship was discussed; only 12 out of the 36 HP's showed antioxidant activity. Polyhydroquinolines (PHQ's) were the most active compounds among the studied HP's, they were characterized by the lack of an ester-like structure substituent at carbon 5.

• 出版日期2012