Nanoelectronic Discrimination of Nonmalignant and Malignant Cells Using Nanotube Field-Effect Transistors

作者：Silva Guilherme O; Michael Zachary P; Bian Long; Shurin Galina V; Mulato Marcelo; Shurin Michael R; Star Alexander

来源：ACS Sensors, 2017, 2(8): 1128-1132.

DOI：10.1021/acssensors.7b00383

• biosensors
• carbon nanotubes
• electronic tongue
• linear discriminant analysis
• metal nanoparticle

Detection of malignant cells in tissue is a difficult hurdle in medical diagnostics and screening. Carbon nanotubes are extremely sensitive to their local environments, and nanotube-based field-effect transistors (NTFETs) provide a plethora of information regarding the mechanism of interaction with target analytes. Herein, we use a series of functionalized metal nanoparticle-decorated NTFET devices forming an array with multiple nonselective sensor units as the electronic tongue, sensing all five basic tastes. By extraction of selected NTFET characteristics and using linear discriminant analysis, we have successfully detected and discriminated between malignant and nonmalignant tissues and cells. We also studied the sensing mechanism and what NTFET characteristics are responsible for the variation of response between cell types, allowing for the design of future studies such as detection of malignant cells in a biopsy or the effects of malignant cells on healthy tissue.

• 出版日期2017-8