Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal

作者：Seck Abdoulaye^*; Mbengue Mouhamadou; Gassama Sow Amy; Diouf Lamine; Ka Mouhamadou Mourtalla; Boye Cheikh Saad Bouh

来源：Journal of Infection in Developing Countries, 2009, 3(2): 137-140.

DOI：10.3855/jidc.512

• Helicobacter pylori
• antimicrobial susceptibility
• Senegal

Background: Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics.
Methodology: H. pylori isolates from gastric biopsies from outpatients >= 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method.
Results: H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs >= 8 mu g/l), whereas all isolates were susceptible to amoxicillin (MICs <= 0. 5 mu g/ml) and ciprofloxacin (MICs <= 1 mu g/ml).
Conclusion: These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.

• 出版日期2009-3