Antifeedant C-20 diterpene alkaloids

作者：Gonzalez Coloma A^*; Reina M; Guadano A; Martinez Diaz R; Diaz JG; Garcia Rodriguez J; Alva A; Grandez M

来源：Chemistry and Biodiversity, 2004, 1(9): 1327-1335.

DOI：10.1002/cbdv.200490095

We have tested the insect antifeedant and toxic activity of 21 C, diterpenoid alkaloids on Spodoptera littoralis and Leptinotarsa decemlineata. The antifeedant effects of the test compounds were structure- and species-dependent. The most active antifeedants to L. decemlineata and S. littoralis were the rearranged form of hetisine (20; EC50 = 1.7 mug/cm(2)) and 19-oxodihydroatisine (9; EC50 = 0.1 mug/cm(2)), resp. Glandulosine (8) moderately affected orally injected S. littoralis larvae. A few compounds (13-oxocardiopetamine (4), 9, and atisinium chloride (13)) had cytotoxic effects to insect-derived Sf 9 cells with varying degrees of selectivity with respect to mammalian CHO cells. Compounds 4 and 15,22-O-diacetyl-19-oxodihydroatisine (10) increased Trypanosoma cruzi mortality. Our results support the plant protective role of C-20 diterpenoid alkaloids and open a new field for parasite control strategies.

• 出版日期2004