A supramolecular hybrid material constructed from pillar[6]arene-based host-guest complexation and ZIF-8 for targeted drug delivery

作者：Yang, Kui; Yang, Ke; Chao, Shuang; Wen, Jia; Pei, Yuxin; Pei, Zhichao^*

来源：Chemical communications, 2018, 54(70): 9817-9820.

DOI：10.1039/c8cc05665j

• CANCER
• THERAPY
• WATER
• BIOACTIVITY
• CHEMISTRY
• DESIGN
• SYSTEM
• CORE

A novel supramolecular hybrid material ZIF-8@DOX@WP6@G constructed from the host-guest complexation between carboxylated pillar[6]arene (WP6) and a galactose derivative (G), and doxorubicin (DOX)-loaded ZIF-8 has been synthesized for targeted drug delivery. The results showed that ZIF-8@DOX@WP6@G not only maintained the pH-sensitive drug release properties of ZIF-8 but also exhibited excellent water dispersibility and selective toxicity for hepatoma cancer cells due to the assembly of WP6 and G. The strategy used in this study opens up a new avenue for constructing multifunctional supramolecular hybrid materials for therapeutic applications in cancer treatment.

• 出版日期2018-9-11
• 单位西北农林科技大学