Association of interleukin-12 gene polymorphisms with cancer susceptibility: a meta-analysis

作者：Chang, Su-Wen^*; Xu, Gui-Qin; Fan, Yong-Ling

来源：International Journal of Clinical and Experimental Medicine, 2015, 8(4): 5317-5322.

• Interleukin 12
• single nucleotide polymorphism
• cervical cancer
• meta-analysis

Objective: To evaluate the association between interleukin-12 (IL-12) gene polymorphism and cervical cancer susceptibility. Methods: We comprehensively retrieved the relevant English and Chinese database to collect case-control studies on the association between the IL-12 gene polymorphism and cervical cancer susceptibility. Data were extracted independently by two researchers respectively, the summary data were analyzed using Revman 5.2 software, the association was described using odds ratios (OR) and 95% confidence intervals (95% CI). Results: According to inclusion and exclusion criteria, 5 case-control studies involving 2552 cervical cancer patients and 2232 healthy controls were included. The meta-analysis results showed that 3'UTR+1188 (rs3212227) polymorphism in IL-12 gene was not associated with cervical cancer risk (C vs. A: OR=1.09, 95% CI: 0.88 similar to 1.35, P=0.45; AA+AC vs. CC: OR=0.88, 95% CI: 0.67 similar to 1.15, P=0.34; AA vs. AC+CC: OR=0.89. 95% CI: 0.56-1.42, P=0.62; CC vs. AA: OR=1.30. 95% CI: 0.79-2.12, P=0.30). Conclusion: The available evidence suggested that rs3212227 polymorphism in IL-12 gene may not be the risk factor to cervical cancer.

• 出版日期2015
• 单位青岛大学; 烟台毓璜顶医院