Donor-Acceptor Substituted Cyclopropane to Butanolide and Butenolide Natural Products: Enantiospecific First Total Synthesis of (+)-Hydroxyancepsenolide

作者：Gharpure Santosh J^*; Nanda Laxmi Narayan; Shukla Manoj Kumar

来源：Organic Letters, 2014, 16(24): 6424-6427.

DOI：10.1021/ol503246k

An oxygen substituted donoracceptor cyclopropane (DAC) is used as a common intermediate in the enantiospecific collective total synthesis of butanolide- and butenolide-based natural products like (+)-juruenolide C and D, (+)-blastmycinone, (+)-antimycinone, and (+)-ancepsenolide. Enantiospecific first total syntheses of (+)-hydroxyancepsenolide and its acetate are achieved confirming their absolute stereochemistry.

• 出版日期2014-12-19