科研之友
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摘要
Purpose: Radiation induced lung injury (RILI) is a common side effect for patients undergoing thoracic radiation therapy (RT). RILI can lead to temporary or permanent loss of lung function and in extreme cases, death. Combining functional lung imaging information with conventional radiation treatment plans may lead to more desirable treatment plans that reduce lung toxicity and improve the quality of life for lung cancer survivors. Magnetic Resonance Imaging of the lung following inhalation of hyperpolarized Xe-129 may provide a useful nonionizing approach for probing changes in lung function and structure associated with RILI before, during, or after RT (early and late time-points). Methods: In this study, dynamic Xe-129 MR spectroscopy was used to measure whole-lung gas transfer time constants for lung tissue and red blood cells (RBC), respectively (T-Tr_tissue and T-Tr_RBC) in groups of rats at two weeks and six weeks following 14 Gy whole-lung exposure to radiation from a Co-60 source. A separate group of six healthy age-matched rats served as a control group. Results: T-Tr_tissue values at two weeks post-irradiation (51.6 +/- 6.8 ms) were found to be significantly elevated (p < 0.05) with respect to the healthy control group (37.2 +/- 4.8 ms). T-Tr_RBC did not show any significant changes between groups. T-Tr_tissue was strongly correlated with T-Tr_RBC in the control group (r = 0.9601 p < 0.05) and uncorrelated in the irradiated groups. Measurements of arterial partial pressure of oxygen obtained by arterial blood sampling were found to be significantly decreased (p < 0.05) in the two-week group (54.2 +/- 12.3 mmHg) compared to those from a representative control group (85.0 +/- 10.0 mmHg). Histology of a separate group of similarly irradiated animals confirmed the presence of inflammation due to radiation exposure with alveolar wall thicknesses that were significantly different (p < 0.05). At six weeks post-irradiation, T-Tr_tissue returned to values (35.6 +/- 9.6 ms) that were not significantly different from baseline. Conclusions: Whole-lung tissue transfer time constants for Xe-129 (T-Tr_tissue) can be used to detect the early phase of RILI in a rat model involving 14 Gy thoracic Co-60 exposure as early as two weeks post-irradiation. This knowledge combined with more sophisticated models of gas exchange and imaging techniques, may allow functional lung avoidance radiation therapy planning to be achievable, providing more beneficial treatment plans and improved quality of life for recovering lung cancer patients.
- 出版日期2014-7
