Fast vaccine design and development based on correlates of protection (COPs) Influenza as a trendsetter

作者：van Els Cecile; Mjaaland Siri; Naess Li**eth; Sarkadi Julia; Gonczol Eva; Korsholm Karen Smith; Hansen Jon; de Jonge Jorgen; Kersten Gideon; Warner Jennifer; Semper Amanda; Kruiswijk Corine; Oftung Fredrik^*

来源：Human Vaccines & Immunotherapeutics, 2014, 10(7): 1935-1948.

DOI：10.4161/hv.28639

• correlates of protection
• influenza
• COP based vaccine design
• vaccine development

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element. In emergency situations, when time is limited, identification and use of correlates of protection (COPs) may play a key role as a strategic tool for accelerated vaccine design, testing, and licensure. We propose that general rules for COP-based vaccine design can be extracted from the existing knowledge of protective immune responses against a large spectrum of relevant viral and bacterial pathogens. Herein, we focus on the applicability of this approach by reviewing the established and up-coming COPs for influenza in the context of traditional and a wide array of new vaccine concepts. The lessons learnt from this field may be applied more generally to COP-based accelerated vaccine design for emerging infections.

• 出版日期2014-7