Development of an enantiodivergent strategy for the total synthesis of (+)- and (-)-dragmacidin F from a single enantiomer of quinic acid

作者：Garg NK; Caspi DD; Stoltz BM^*

来源：Journal of the American Chemical Society, 2005, 127(16): 5970-5978.

DOI：10.1021/ja040588v

An enantiodivergent strategy for the total chemical synthesis of both (+)- and (-)-dragmacidin F beginning from a single enantiomer of quinic acid has been developed and successfully implemented. Although unique, the synthetic routes to these antipodes share a number of key features, including novel reductive isomerization reactions, Pd(II)-mediated oxidative carbocyclization reactions, halogen-selective Suzuki couplings, and high-yielding late-stage Neber rearrangements.

• 出版日期2005-4-27