fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin

作者：Pelegrino Karla de Oliveira; Campos Juliana Coutinho; Ferreira Sampaio Suely Carlos; Lezirovitz Karina; Seco Bruna Mara; Pereira Mayne de Oliveira; da Costa Rocha Darlan Augusto; Jove Thomas; Nicodemo Antonio Carlos; Mello Sampaio Jorge Luiz

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(1): 686-688.

DOI：10.1128/AAC.02437-15

In this work, we demonstrate that the fosI gene encodes a predicted small protein with 134 amino acids and determines reduced susceptibility to fosfomycin. It raised the MIC from 0.125 to 6 mu g/ml when the pBRA100 plasmid was introduced into Escherichia coli TOP10 and to 16 mu g/ml when the gene was cloned into the pBC_SK(-) vector and expressed in E. coli TOP10.

• 出版日期2016-1