Advances in ginsenoside biosynthesis and metabolic regulation

作者：Lu Jun; Li Jinxin; Wang Shihui; Yao Lu; Liang Wenxia; Wang Juan^*; Gao Wenyuan^*

来源：Biotechnology and Applied Biochemistry, 2018, 65(4): 514-522.

DOI：10.1002/bab.1649

• Panax genus
• ginsenoside biosynthesis
• metabolic regulation
• elicitor

In this paper, we reviewed the advances in ginsenoside biosynthesis and metabolic regulation. To begin with, the application of elicitors in the ginsenoside biosynthesis was discussed. Methyl jasmonate (MJ) and analogues have the best effect on accumulation of ginsenoside compared with other elicitors, and few biotic elicitors are applied in Panax genus plants tissue culture. In addition, so far, more than 40 genes encoding ginsenoside biosynthesis related enzymes have been cloned and identified from Panax genus, such as UDP-glycosyltransferases (UGT) genes UDPG, UGTAE2, UGT94Q2, UGTPg100, and UGTPg1. However, the downstream pathway of the ginsenoside biosynthesis is still not clear. Moreover, some methods have been used to increase the expression of functional genes and ginsenoside content in the ginsenoside synthesis pathway, including elicitors, overexpression, RNAi, and transcription factors. The ginsenoside biosynthesis pathway should be revealed so that ginsenoside contents can be regulated.

• 出版日期2018-8
• 单位天津大学; 天津科技大学