Arylboronate Ester Based Diazeniumdiolates (BORO/NO), a Class of Hydrogen Peroxide Inducible Nitric Oxide (NO) Donors

作者：Dharmaraja Allimuthu T; Ravikumar Govindan; Chakrapani Harinath^*

来源：Organic Letters, 2014, 16(10): 2610-2613.

DOI：10.1021/ol5010643

Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors%26apos; ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS.

• 出版日期2014-5-16