A straightforward and versatile approach to the synthesis of 1,4,5-trisubstituted 1,2,3-triazoles from alkyl halides via a one-pot, three-component reaction

作者：Gonzalez Calderon Davir^*; Aguirre De Paz Jose G; Gonzalez Gonzalez Carlos A; Fuentes Benites Aydee; Gonzalez Romero Carlos

来源：Tetrahedron Letters, 2015, 56(13): 1713-1715.

DOI：10.1016/j.tetlet.2015.02.049

• Triazoles
• Alkyl halides
• Azide-enolate cycloaddition
• Dimroth cycloaddition

The preparation of 1,4,5-trisubstituted 1,2,3-triazoles by the coupling of three components (alkyl halides, sodium azide, and active ketones) through an azide-enolate [3+2] cycloaddition (Dimroth cycloaddition) has been developed for the first time. A wide variety of halides (including chlorides, bromides, and iodides as well as primary and secondary derivatives) have demonstrated the versatility of this method, which is based on a one-pot system under mild reaction conditions.

• 出版日期2015-3-25