Microstructural characterization and in vitro bioactivity of porous glass-ceramic scaffolds for bone regeneration by synchrotron radiation X-ray microtomography

作者：Renghini Chiara; Giuliani Alessandra; Mazzoni Serena; Brun Francesco; Larsson Emanuel; Baino Francesco^*; Vitale Brovarone Chiara

来源：Journal of the European Ceramic Society, 2013, 33(9): 1553-1565.

DOI：10.1016/j.jeurceramsoc.2012.10.016

• X-ray microtomography
• Glass-ceramic scaffold
• Sponge replication
• In vitro bioactivity
• Bone tissue engineering

One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body%26apos;s own regenerative mechanism for patient%26apos;s anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are carried out on Bioglass (R)- and CEL2-derived scaffolds produced by sponge replication (CEL2 is an experimental glass developed at Politecnico di Torino). Synchrotron radiation X-ray microtomography is used to study the samples 3-D architecture, pores size, shape, distribution and interconnectivity, as well as the growth kinetics on scaffolds struts of a newly formed apatitic phase during in vitro treatment in simulated body fluid, in order to describe from a quantitative viewpoint the bioactive potential of the analyzed biomaterials. An accurate comparison between architectural features and bioactive behaviour of Bioglass (R)- and CEL2-derived scaffolds is presented and discussed.

• 出版日期2013-8