An eco-friendly tandem tosylation/Ferrier N-glycosylation of amines catalyzed by Er(OTf)(3) in 2-MeTHF

作者：Nardi Monica^*; Cano Natividad Herrera; De Nino Antonio; Di Gioia Maria Luisa; Maiuolo Loredana; Oliverio Manuela; Santiago Ana; Sorrentino Diletta; Procopio Antonio

来源：Tetrahedron Letters, 2017, 58(18): 1721-1726.

DOI：10.1016/j.tetlet.2017.03.047

• 2-MeTHF
• Glycosylation
• Green chemistry
• Sulfonamidoglycosides

Er(OTf)(3) in 2-MeTHF provides a new and eco-friendly process for Ferrier glycosylation of sulfonamides and amino acids with various N-nucleophiles. The stereoselective synthesis of 2,3-unsaturated-N-pseudoglycals was carried out with 3,4,6-tri-O-acetyl-d-glucal and different nucleophiles affording good results in a short time.

• 出版日期2017-5-3