Algorithm of Golgi protein 73 and liver stiffness accurately diagnoses significant fibrosis in chronic HBV infection

作者：Cao, Zhujun; Li, Ziqiang; Wang, Hui; Liu, Yuhan; Xu, Yumin; Mo, Ruidong; Ren, Peipei; Chen, Lichang; Lu, Jie; Li, Hong; Zhuang, Yan; Liu, Yunye; Wang, Xiaolin; Zhao, Gangde; Tang, Weiliang; Xiang, Xiaogang; Cai, Wei; Liu, Longgen; Bao, Shisan; Xie, Qing^*

来源：Liver International, 2017, 37(11): 1612-1621.

DOI：10.1111/liv.13536

• Golgi protein 73
• liver stiffness
• non-invasive
• significant fibrosis

Background & AimsSerum Golgi protein 73 (GP73) is a potential biomarker for fibrosis assessment. We aimed to develop an algorithm based on GP73 and liver stiffness (LS) for further improvement of accuracy for significant fibrosis in patients with antiviral-naive chronic hepatitis B virus (HBV) infection. @@@ MethodsDiagnostic accuracy evaluation of GP73 and development of GP73-LS algorithm was performed in training cohort (n=267) with an independent cohort (n=133) for validation. @@@ ResultsA stepwise increasing pattern of serum GP73 was observed across fibrosis stages in patients with antiviral-naive chronic HBV infection. Serum GP73 significantly correlated (rho=0.48, P<.001) with fibrosis stage and was an independent predictor for the presence of significant fibrosis (OR, 95%CI: 1.02, 1.01-1.03, per increase in 1ng/mL, P<.001). Both LS (AUROC, 95%CI: 0.82, 0.77-0.87, accuracy: 74.7%) and GP73 (AUROC, 95%CI: 0.76, 0.71-0.82, accuracy: 71.5%) well-predicted significant fibrosis and outperformed APRI (AUROC, 95%CI: 0.69, 0.63-0.76, accuracy: 66%) and FIB-4 (AUROC, 95%CI: 0.66, 0.60-0.73, accuracy: 63.6%). Using GP73-LS algorithm, GP73<63 in agreement with LS<8.5 provided accuracy of 81.7% to excluded significant fibrosis. GP7363 in agreement with LS8.5 provided accuracy of 93.3% to confirm significant fibrosis. Almost 64% or 68% of patients in the training or validation cohort could be accurately classified. @@@ ConclusionsSerum GP73 is a robust biomarker for significant fibrosis diagnosis. GP73-LS algorithm provided better diagnostic accuracy than currently available approaches. More than 60% antiviral naive CHB patients could use this algorithm without resorting to liver biopsy. @@@ See Editorial on Page 1605

• 出版日期2017-11
• 单位上海交通大学; 上海市闵行区中心医院