A PIAS-ed view of DNA double strand break repair focuses on SUMO

作者：Zlatanou Anastasia; Stewart Grant S^*

来源：DNA Repair, 2010, 9(5): 588-592.

DOI：10.1016/j.dnarep.2010.02.003

• SUMO
• PIAS
• DNA damage response
• BRCA1
• 53BP1

Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as important regulators of the DDR network. Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage.

• 出版日期2010-5-4