Drug prescriptions of adults with adolescent depression in a community sample

作者：Paaren Aivar^*; von Knorring Lars; Jonsson Ulf; Bohman Hannes; Olsson Gunilla; von Knorring Anne Liis

来源：Pharmacoepidemiology and Drug Safety, 2012, 21(2): 130-136.

DOI：10.1002/pds.2120

• adolescent depression
• follow-up
• prescription drugs

Purpose The prescription drugs have, to our knowledge, not been much studied in epidemiological samples with long-term follow-up. Accordingly, our purpose was to analyze the use of prescription drugs in adults with adolescent depression. %26lt;br%26gt;Methods A population-based cohort of adolescents (n = 2465) was screened for the presence of depressive symptoms and diagnosed according to a structured interview. Totally, 362 individuals were identified as depressed and compared with 250 non-depressed controls. The prescription drugs were evaluated at the age of 29-31 years from a register kept by the National Health and Welfare Board. %26lt;br%26gt;Results The formerly depressed females received significantly more prescription drugs, such as antidepressants, antiepileptics, antibacterials, antimycotics, and antihistamines for systemic use as well as other drugs, compared with controls (15.6 +/- 27.4 vs 8.2 +/- 7.4 recipes, p %26lt; 0.001). Formerly depressed males did not differ from controls regarding prescription drugs. %26lt;br%26gt;Conclusions The females but not males with adolescent depression subsequently received more prescription drugs than non-depressed peers. Depressed female adolescents received more psychotropic and non-psychotropic drugs later in life compared to the non-depressed. This might be as a result of physical illnesses, different treatment-seeking behaviors, or somatizing reactions.

• 出版日期2012-2