Acid-base organocatalysts for the aza-Morita-Baylis-Hillman reaction of nitroalkenes

作者:Takizawa Shinobu*; Horii Atsushi; Sasai Hiroaki
来源:Tetrahedron: Asymmetry , 2010, 21(8): 891-894.
DOI:10.1016/j.tetasy.2010.05.027

摘要

A new class of acid-base chiral organocatalysts 1a and 2 for aza-Morita-Baylis-Hillman (aza-MBH) reaction of conjugated nitroalkenes is described. The acidic phenolic hydroxy groups and basic imidazole unit cooperatively activate nitroalkenes to promote the aza-MBH reaction in good yields with moderate enantioselectivities.

  • 出版日期2010-4-30