NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones

作者：Weinman Edward J^*; Lederer Eleanor D

来源：American Journal of Physiology - Renal Fluid and Electrolyte Physiology, 2012, 303(3): F321-F327.

DOI：10.1152/ajprenal.00093.2012

• dopamine
• FGF-23
• parathyroid hormone

Weinman EJ, Lederer ED. NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol 303: F321-F327, 2012. First published April 25, 2012; doi:10.1152/ajprenal.00093.2012.-The renal excretion of inorganic phosphate is regulated in large measure by three hormones, namely, parathyroid hormone, dopamine, and fibroblast growth factor-23. Recent experiments have indicated that the major sodium-dependent phosphate transporter in the renal proximal tubule, Npt2a, binds to the adaptor protein sodium-hydrogen exchanger regulatory factor-1 ( NHERF-1) and in the absence of NHERF-1, the inhibitory effect of these three hormones is absent. From these observations, a new model for the hormonal regulation of renal phosphate transport was developed. The downstream signaling pathways of these hormones results in the phosphorylation of the PDZ 1 domain of NHERF-1 and the dissociation of Npt2a/NHERF-1 complexes. In turn, this dissociation facilitates the endocytosis of Npt2a with a subsequent decrease in the apical membrane abundance of the transporter and a decrease in phosphate reabsorption. The current review outlines the experimental observations supporting the operation of this unique regulatory system.

• 出版日期2012-8