科研之友
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摘要
Endo-pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane-8-ol (5) was a key intermediate in the research of anti-influenza viruses medicines, anti-inflammatory drugs, high energy fuels and fuel additives. The synthesis of endo-pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane-8-ol (5) was successfully achieved by a six steps route which was consisted of Diels-Alder, photo-cyclo addition, carbonyl protecting, lithium aluminium hydride reduction, hydrolysis and Huang-Minlon reduction. The total yield was 44.9%. This method has the advantages of facilely available starting materials, simply conducted procedures, relatively high yield and easy purification, and is more suitable for scale-up production.
