Alteration of the Beta-Adrenergic Signaling Pathway in Human Heart Failure

作者：Hamdani Nazha^*; Linke Wolfgang A

来源：Current Pharmaceutical Biotechnology, 2012, 13(13): 2522-2531.

• Heart failure
• beta adrenergic receptors
• myofilament proteins
• cardiomyocytes

Heart failure is characterized by elevated circulating catecholamine levels and extensive abnormalities in beta-adrenergic receptor signaling. Under physiological conditions, sympathetic modulation via catecholamines induces positive inotropic, chronotropic and lusitropic responses. Well established in heart failure patients is a pronounced activation of the sympathetic system, accompanied by downregulation and desensitization of beta-adrenergic receptors, leading to a markedly diminished beta-adrenergic contractile response. In this review, we will discuss the normal beta-adrenergic receptor signaling pathway in the heart and focus on the pathphysiological alterations of beta-adrenergic receptor signaling and contractile proteins in heart failure.

• 出版日期2012-10