Anterior lens capsule and epithelium thickness measurements using spectral-domain optical coherence tomography

作者：Dong, Jing; Jia, Yading; Zhang, Yaqin; Zhang, Haining; Jia, Zhijie; Zhang, Suhua; Wu, Qiang; Hu, Qingmao; Zhang, Tianqiao; Wang, Xiaogang^*

来源：BMC Ophthalmology, 2017, 17(1): 94.

DOI：10.1186/s12886-017-0489-0

• Anterior lens capsular complex
• Pupillary diameter
• Optical coherence tomography
• Signal strength index

Background: To investigate the anterior lens capsule and epithelium thickness (defined as anterior lens capsular complex: ALCC) in normal Chinese subjects using spectral-domian optical coherence tomography (SD-OCT) and examine the factors that may influence the ALCC, such as age, gender, pupil diameter (PD) and signal strength index (SSI).
Methods: A prospective observational case series. One-hundred-thirty-four normal subjects (134 eyes) were included. The ALCCs were determined manually via SD-OCT. Using the pupil center as a reference position, the central ALCC (CALCC), nasal 1-mm ALCC (NALCC), temporal 1-mm ALCC (TALCC) and PD were measured manually.
Results: The mean CALCC, NALCC and TALCC were 33 +/- 6 mu m, 36 +/- 7 mu m and 34 +/- 6 mu m, respectively. The NALCC was significantly thicker than the CALCC (P < .001) and TALCC (P < .001). Moreover, CALCC was significantly thinner than TALCC (P = 0.013). Age was positively correlated with the CALCC (r = 0.292, P < .001), NALCC (r = 0.400, P < .001) and TALCC (r = 0.521, P < .001). PD, gender and SSI were not significantly correlated with the three ALCC parameters.
Conclusions: The SD-OCT can be used to demonstrate the ALCC thickness, and age is positively correlated with the ALCC in the central, nasal and temporal sides.

• 出版日期2017-6-19
• 单位中国科学院深圳先进技术研究院; 中国科学院大学; 山西医科大学; 上海交通大学; 山西省眼科医院