Medications as a source of paraben exposure

作者：Dodge Laura E; Kelley Katherine E; Williams Paige L; Williams Michelle A; Hernandez Diaz Sonia; Missmer Stacey A; Hauser Russ^*

来源：Reproductive Toxicology, 2015, 52: 93-100.

DOI：10.1016/j.reprotox.2015.02.002

• Parabens
• Endocrine system
• Pharmaceuticals
• Assisted Reproductive Technologies

Background: Parabens are used as antimicrobial excipients in some pharmaceuticals. Parabens may adversely affect reproduction.
Objectives: Determine whether paraben-containing medication contributes to high urinary paraben concentrations.
Methods: Individuals at a fertility clinic provided multiple urine samples during evaluation/treatment and reported 24-h use of medications and personal care products (PCP). Repeated measures models compared specific gravity-adjusted urinary methyl, propyl, and butyl paraben concentrations between samples "exposed" and "unexposed" to paraben-containing medication.
Results: Eleven participants contributed 12 exposed and 45 unexposed samples, among which paraben concentrations did not differ. Use within 7 h was associated with 8.7-fold and 7.5-fold increases in mean methyl (P = 0.11) and propyl (P = 0.10) paraben concentrations, respectively, after adjusting for PCP use. However, these associations decreased to 1.3-fold (P = 0.76) and 2.6-fold (P = 0.34), respectively, after removal of one influential individual.
Conclusion: Paraben-containing medications contributed to higher urinary paraben concentrations within hours of use.

• 出版日期2015-4