Assessment of aflatoxin exposure among young children in Ethiopia using urinary biomarkers

作者：Ayelign Abebe^*; Woldegiorgis Ashagrie Zewdu; Adish Abdulaziz; De Boevre Marthe; Heyndrickx Ellen; De Saeger Sarah

来源：Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure& Risk Assessment, 2017, 34(9): 1606-1616.

DOI：10.1080/19440049.2017.1350290

• Biomarker
• urine
• aflatoxin
• children
• exposure assessment

The direct measurement of biomarkers of exposure in biological fluids such as urine has become important for assessing aflatoxin exposure in humans as it is the only tool that integrates exposures from various routes. For this reason, a study was conducted to assess aflatoxin exposure among young children in Ethiopia using urinary biomarkers. A cross-sectional study was conducted in ten Woredas (Districts) from Amhara and Tigray regional states of Ethiopia including 200 children (aged 1-4years). A total of 200 urine samples were collected from 200 children and assessed for the levels of aflatoxin B-1 (AFB(1)), aflatoxin B-2 (AFB(2)), aflatoxin G(1) (AFG(1)), aflatoxin G(2) (AFG(2)) and aflatoxin M-1 (AFM(1)) using a validated LC-MS/MS method. Aflatoxins were detected in 34/200 (17%) of the urine samples whereby four out of five analysed aflatoxins were detected. AFM(1) was detected in 14/200 (7%) of the urine samples in a range of 0.06-0.07ng/mL. AFB(2), AFG(2) and AFG(1) were detected in respectively 9/200 (4.5%), 6/200 (3%) and 5/200 (2.5%) of the urine samples whereas AFB(1) was not detected in any of the samples. In this study, there was no association between the different malnutrition categories (stunted, wasting and underweight) and aflatoxin exposure. However, the biomarker analysis showed a clear exposure of young children to aflatoxins. Therefore, awareness to the public is important to prevent potential health consequences of aflatoxins.

• 出版日期2017