Association of Antepartum and Postpartum Depression in Ghanaian and Ivorian Women With Febrile Illness in Their Offspring: A Prospective Birth Cohort Study

作者：Guo Nan; Bindt Carola; Te Bonle Marguerite; Appiah Poku John; Hinz Rebecca; Barthel Dana; Koffi Mathurin; Posdzich Sarah; Deymann Simon; Barkmann Claus; Schlueter Lisa; Jaeger Anna; Nguah Samuel Blay; Eberhardt Kirsten A; N'Goran Eliezer; Tagbor Harry; Ehrhardt Stephan^*

来源：American Journal of Epidemiology, 2013, 178(9): 1394-1402.

DOI：10.1093/aje/kwt142

• Africa
• children
• depression
• febrile illness
• motherhood
• pregnancy
• puerperium
• women

In low-income countries, perinatal depression is common, but longitudinal data on its influence on child health are rare. We examined the association between maternal depression and febrile illness in children. There were 654 mother/child dyads in Ghana and Cte dIvoire that were enrolled in a prospective birth cohort in 20102011 and underwent 2-years of follow up. Mothers were examined for depression using the Patient Health Questionnaire depression module antepartum and 3 and 12 months postpartum. The hazard of febrile illness in children of depressed and nondepressed mothers was estimated using a recurrent event Cox proportional hazards model. The prevalences of antepartum depression in mothers from Cte dIvoire and Ghana were 28.3 and 26.3, respectively. The prevalences of depression at 3 and 12 months postpartum were 11.8 and 16.1 (Cte dIvoire) and 8.9 and 7.2 (Ghana). The crude and adjusted (for country and socioeconomic status) hazard ratios of febrile illness in children of depressed mothers compared with those in children of nondepressed mothers were 1.57 (95 confidence interval: 1.20, 2.07) and 1.32 (95 confidence interval: 1.01, 1.74) respectively. Perinatal depression was frequent and associated with febrile illness in the offspring. Our results showed that a high prevalence of depression in sub-Saharan Africa may pose a serious public health threat to women and their offspring.

• 出版日期2013-11-1