Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti-inflammatory drugs in the low mu g center dot L-1 concentration range

作者：Macia A; Borrull F; Aguilar C; Calull M^*

来源：Electrophoresis, 2004, 25(3): 428-436.

DOI：10.1002/elps.200305707

• capillary electrophoresis
• large-volume sample stacking using the EOF pump
• nonsteroidal anti-inflammatory drugs
• water samples

Several on-column sample preconcentration modes-large-volume sample stacking using the EOF pump (LVSEP), LVSEP with anion-selective exhaustive injection (LVSEP-ASEI) and field-amplified sample injection with sample matrix removal using the electroosmotic flow (EOF) pump (FAEP)-were used to analyze some nonsteroidal anti-inflammatory drugs (NSAIDs) by capillary electrophoresis, and then compared. Methanol was the background electrolyte solvent to suppress the EOF The effect of the type and length of the solvent plug, and the sample injection time were investigated in FAEP to determine the conditions that provided the best response. LVSEP, LVSEP-ASEI, and FAEP improved the sensitivity of the peak area by 100-, 1200-, and 1800-fold, respectively. The methodology developed, in combination with solid-phase extraction (SPE), was applied to the analysis of water samples.

• 出版日期2004-2