科研之友
微信
新浪微博
Facebook
分享链接
摘要
Some 15-20% of the population over the age of 65 years suffer horn dementia, currently one of the leading causes of death behind cardiovascular diseases, cancer and cerebrovascular diseases The major forms of dementia shore in common overactivatron of the CD40-CD40-L complex, leading to high levels of proinflammatory cytokine production by Immune cells of the central nervous system (CNS), including microglia and astrocytes Consequently, both neuronal survival and signaling are negatively affected, leading to the characteristic progressive loss of higher cortical functions We have reviewed the literature concerning the involvement of this complex in the pathology of three motor forms of dementia Alzheimer's-type, HIV-associated and vascular dementia This is followed by a discussion of current preclinical and clinical therapies that may influence this interaction, and thus point the way toward a future neuroimmunologicol approach to inhibiting the effects of CD40-CD40-L in neuropsychiatric disease.
- 出版日期2009-4
