Health state utility valuation in radioactive iodine-refractory differentiated thyroid cancer

作者：Fordham Beth A; Kerr Cicely; de Freitas Hayley M^*; Lloyd Andrew J; Johnston Karissa; Pelletier Corey L; Tremblay Gabriel; Forsythe Anna; McIver Bryan; Cohen Ezra E W

来源：Patient Preference and Adherence, 2015, 9: 1561-1571.

DOI：10.2147/PPA.S90425

• differentiated thyroid cancer
• radioactive iodine-refractory
• health-related quality of life
• health utility
• vignette

Purpose: The aim of this study was to elicit utilities for radioactive iodine-refractory differentiated thyroid cancer (RR-DTC) and evaluate the impact of treatment response and toxicities on quality of life.
Patients and methods: RR-DTC health states were developed based on data from a previous qualitative study and iterative review by clinical experts. Following piloting, health states underwent valuation by 100 members of the UK public during time trade-off interviews. Mean utilities and descriptive distribution statistics were calculated, and a logistic regression analysis was conducted.
Results: The demographic characteristics of the study sample were generally reflective of the UK population. Clear differentiation in valuation between health states was observed. No response/stable disease had an adjusted utility value of 0.87, with a corresponding gain of +0.04 following a treatment response and a decline of -0.35 for disease progression. Adverse events were associated with utility decrements between -0.47 (grade III diarrhea) and -0.05 (grade I/II alopecia).
Conclusion: The trade-off interviews derived utility weights show clear differentiation between RR-DTC health states in response to treatment. The values reported in this study are suitable for cost-effectiveness evaluations for new treatments in RR-DTC.

• 出版日期2015