Discrimination of Breast Cancer from Normal Tissue with Raman Spectroscopy and Chemometrics

作者：Li Q B; Wang W; Liu Ch H; Zhang G J^*

来源：Journal of Applied Spectroscopy, 2015, 82(3): 450-455.

DOI：10.1007/s10812-015-0128-6

• breast cancer
• miniature Raman spectrometer
• adaptive local hyperplane K-nearest neighbor (ALHK)

Conventional Raman spectra of normal and cancerous breast tissues were acquired at an excitation wavelength of 785 nm and subjected to a discrimination analysis. First the spectra were pretreated with wavelet transform and polynomial fitting; next, cancerous tissue was identified by applying an adaptive local hyperplane K-nearest neighbor (ALHK) method to the pretreated spectra. The best discrimination accuracy of the ALHK method was 93.2%. In summary, normal and cancerous breast tissue were accurately distinguished by a miniature laser Raman spectrometer and the chemometrics method (ALHK), which might prove to be a portable and accessible diagnostic system.

• 出版日期2015-7
• 单位北京航空航天大学