Apoptosis induced by BIK was decreased with RNA interference of caspase-12

作者：Zhao, Xiaoping; Sun, Yan; Yu, Hai; Ye, Ling; Zhang, Leilei; Lu, Jian; Yuan, Yaozong; Qian, Guanxiang; Ge, Shengfang^*

来源：Biochemical and Biophysical Research Communications, 2007, 359(4): 896-901.

DOI：10.1016/j.bbrc.2007.05.175

• BIK
• caspase-12
• apoptosis
• RNAi

BIK, a member of the Bcl-2 family, has been reported to induce cell apoptosis but the underlying mechanisms are not well delineated. We used siRNA targeting caspase-12 to examine the effect of caspase-12 on apoptosis induced by BIK. In this study, we show that caspase-12 was activated by BIK. With caspase-12 knocked down, the apoptosis induced by BIK was decreased substantially. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced.

• 出版日期2007-8-10
• 单位上海交通大学; 上海市闵行区中心医院