Antisecretory medication is associated with decreased Helicobacter pylori detection in gastric marginal zone lymphoma

作者：Schaberg Kurt B; Evans Mark F; Wilcox Rebecca; Lewis Michael R^*

来源：Annals of Diagnostic Pathology, 2015, 19(6): 397-402.

DOI：10.1016/j.anndiagpath.2015.10.001

• Helicobacter pylori
• Gastric marginal zone lymphoma
• Mucosa-associated lymphoid tissue
• Antisecretoty medication

Helicobacter pylori status influences the prognosis and management of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), so accurate determination of H pylori status is of clinical importance. The low rate of histologic H pylori positivity among gastric MALT lymphoma cases at our institution prompted investigation for possible causes. A case series of 24 patients as having gastric MALT lymphoma (with no diffuse large B-cell component) in a tertiary care setting between 1997 and 2010 was identified, and clinical records were reviewed. Immunohistochemical staining for H pylori and BCL10 was performed. This study received institutional review board approval (protocol number M13-033). Thirty-nine percent of cases (9/23) were H pylori positive by histology, and 4 additional patients had positive serologic results; overall, 57% of cases (13/23) were positive for H pylori. Treatment with antisecretory medications was associated with a lower likelihood of histologic positivity (13% among treated patients vs 75% among untreated; P = .04). Nuclear localization of BCL10 was seen in 2 cases and was not associated with H pylori status. Antisecretory medications decrease the likelihood of histologic detection of H pylori in gastric MALT lymphoma cases. Incorporation of results of serologic or other testing is needed to ensure correct classification with respect to H pylon status.

• 出版日期2015-12